Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population. Interventions to slow human aging will need to be applied to still-young individuals. However, most human aging research examines older adults, many with chronic disease. As a result, little is known about aging in young humans. We studied aging in 954 young humans, the Dunedin Study birth cohort, tracking multiple biomarkers across three time points spanning their third and fourth decades of life. We developed and validated two methods by which aging can be measured in young adults, one cross-sectional and one longitudinal. Our longitudinal mea- sure allows quantification of the pace of coordinated physiological deterioration across multiple organ systems (e.g., pulmonary, periodontal, cardiovascular, renal, hepatic, and immune function). We applied these methods to assess biological aging in young humans who had not yet developed age-related diseases. Young individuals of the same chronological age varied in their “biological aging” (declining integrity of multiple organ systems). Already, before midlife, individuals who were aging more rapidly were less physically able, showed cognitive decline and brain aging, self- reported worse health, and looked older. Measured biological aging in young adults can be used to identify causes of aging and evaluate rejuvenation therapies.
width
OUTsole
PRODUCED
vegan
brand strengths
Anatomical Design: These sneakers are crafted to follow the natural shape of your feet, allowing for free movement and promoting overall body flexibility.
Vegan-Friendly: Committed to ethical production, Fleeters' Peach Leopard sneakers are 100% vegan, aligning with sustainable and cruelty-free practices.
Handcrafted Quality: Handmade in Portugal, Fleeters ensures meticulous craftsmanship, resulting in durable and high-quality footwear.
Minimalist Sole: Featuring a thin 5mm sole, they provide a heightened sensory experience, enhancing your connection to the ground and promoting better posture and balance.
MFF Summary
The Fleeters are fairly priced and designed for medium-width feet. The toe box tapers slightly early, so we recommend sizing up for a better fit. Durability is excellent, materials are breathable, and the dual insole options add versatility. The thin sole enhances ground feel, making them ideal for nature walks. Made and shipped within the EU, this is a brand we highly recommend.
watch our review
This video provides a detailed, in-depth review of the shoes, covering our key assessment points such as toe box space, flexibility, durability, and overall comfort. After 30 days of consistent wear, we share our discoveries on how the shoes perform in real-life conditions. Our final evaluation, including individual category scores, is displayed below.
TOE BOX
FLEXIBILITY
DURABILITY
INNER VOLUME
HEEL DROP
WEIGHT
COMFORT
ANATOMICAL FIT
assessing
At My Foot Function, we begin by thoroughly assessing the structure of each shoe. With our extensive knowledge of shoe manufacturing and foot function, we look beyond the surface, identifying the hidden clues that determine how a shoe will impact foot health and function. Every detail matters, from materials to design, ensuring we evaluate each shoe with precision and expertise.
testing
The testing phase starts with real-world use—we wear the shoes consistently for 14-28 days, using them exactly as intended. During this period, we analyze their effect on foot health, weight distribution, and overall comfort. To go even deeper, we cut some shoes open to examine their internal structure, revealing insights that aren't visible from the outside.
approval
Shoes that pass our testing process are MFF-approved, meeting our core principles of foot health and functionality. Approved shoes are then categorized by foot width, ensuring you find the right fit. Our goal is to be as descriptive as possible, providing a detailed breakdown of each shoe based on our rigorous assessment and testing process.
about us
Over the years, we've collaborated with some of the biggest brands in functional footwear, advising on development and education. This deep expertise allows us to test shoes at an entirely new level, focusing purely on function over style. Our mission is to provide unbiased, research-driven insights, helping you make informed choices for your foot health.
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Subtalar Joint Axis Location and Rotational
Comparison between shoe wearing population and barefoot